Now, Twilight and Spike aren't my favorite characters. Nay, that is Applejack and Rainbow Dash and apparently Fluttershy as of Season 5 weirdly enough. However, they *do* possess my favorite friendship of the show. They really feed off of each other for great moments and great episodes, and their extensive history makes them always a treat to watch. 

Song is "Come On" by Panic! At the Disco and Fun.